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KMID : 0359819940230060607
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Journal of Korean Neurosurgical Society
1994 Volume.23 No. 6 p.607 ~ p.614
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The Effects of Nimodipine, Induced Hypertension, and Combined Nimodipine Therapies with Induced Hypertension on Experimental Cerebral Infarction
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서영호
김인홍/이장철/손은익/김동원/임만빈
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Abstract
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The treatment with nimodipine is recommended as an effective therapy for the delayed ischemic neurological deficits (DIND) caused by cerebral vasospasm following aneurysmal subarachnoid hemorrhage. The induced hypertension is also widely accepted
as a
treatment method to reverse the DIND caused by cerebral vasospasm. Therefore, the combination of these two regimens may be considered as a more effective treatment method for the DIND than nimodipine or induced hypertension alone. The authors
performed
this experimental study to clear up this subject.
In a series of 60 adult rats, a surgical occlusion of the middle cerebral artery (MCA) was carried out by a microsurgical technique. The animals were divided into 4 groups as follows; group I (N=15) : control group, group II (N=15) : nimodipine
treated
group, group III (N=15) : induced hypertension group, group IV (N=15) : combined nimodipine treated with induced hypertension group, Group II animals were treated with an infusion of nimodipine intravenously (1 ㎍/Kg/min), and group III animals
were
maintained high blood pressure (B. P). to 160 mmHg by an infusion of dopamine intravenously (2㎍/Kg/min), and group IV animals were treated with an infusion of nimodipine and dopamine intravenously.
All animals of each group were sacrificed at 6, 12 and 24 hours after MCA occlusion. Then the brain slices were obtained and stained with triphenyltetrazollum chloride (TTC). The size of the infarction area was quantified by a computer image
analysis
system and the size of the infarction area compared among each groups.
The results showed that each size of the infarction area according to sacrifice time at 6, 12 and 24 hours after MCA occlusion was significantly smaller in group II, III, IV than that of group I(P<0.05). The total size of the infarction area was
significantly smaller in group II, III and IV than that of group I (group I vs. II vs. IV ; 13.23±2.60 vs. 9.17±2.23 vs. 10.24±2.23 vs. 8.85±2.23%, respectively. group I vs. II, III and IV : p<0.05). However, there was not noticed any
significant
difference in the size of the infarction area among group II, III and IV.
This study concludes that the treatment of the combined nimodipine with induced hyperten sion has no more benefit for the improving infarction in the permanent focal ischemic model than nimodipine or induced hypertension treatment alone.
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KEYWORD
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